Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
Identifieur interne : 001D73 ( Main/Exploration ); précédent : 001D72; suivant : 001D74Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
Auteurs : Robert J. Mentz [États-Unis] ; Lothar Roessig [Allemagne] ; Barry H. Greenberg [États-Unis] ; Naoki Sato [Japon] ; Kaori Shinagawa [Japon] ; Daniel Yeo [Singapour] ; Bernard W. K. Kwok [Singapour] ; Eugenio B. Reyes [Philippines] ; Henry Krum [Australie] ; Burkert Pieske [Allemagne] ; Stephen J. Greene [États-Unis] ; Andrew P. Ambrosy [États-Unis] ; Jacob P. Kelly [États-Unis] ; Faiez Zannad [France] ; Bertram Pitt [États-Unis] ; Carolyn S. P. Lam [Singapour]Source :
- JACC. Heart failure [ 2213-1779 ] ; 2016.
Abstract
Heart failure (HF) is a major and increasing global public health problem. In Asia, aging populations and recent increases in cardiovascular risk factors have contributed to a particularly high burden of HF with similarly poor outcomes compared to the rest of the world. Representation of Asians in landmark HF trials has been variable. In addition, HF patients from Asia demonstrate clinical differences from other geographic regions. Thus, the generalizability of some clinical trials results to the Asian population remains uncertain. In this manuscript, we review differences in the HF phenotype, management and outcomes in patients from East and Southeast Asia. We describe lessons learned in Asia from recent HF registries and clinical trial databases and outline strategies to improve the potential for success in future trials. This review is based on discussions between scientists, clinical trialists, industry representatives and regulatory representatives at the CardioVascular Clinical Trialist Asia Forum on July 4, 2014.
Url:
DOI: 10.1016/j.jchf.2016.01.013
PubMed: 27256745
PubMed Central: 4893168
Affiliations:
- Allemagne, Australie, France, Japon, Philippines, Singapour, États-Unis
- Berlin, Californie, Caroline du Nord, Grand Est, Lorraine (région), Michigan, Région de Kantō, Victoria (État)
- Berlin, Melbourne, Nancy, Tokyo
- Université de Lorraine
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Mentz</name><affiliation wicri:level="2"><nlm:aff id="A1">Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Roessig, Lothar" sort="Roessig, Lothar" uniqKey="Roessig L" first="Lothar" last="Roessig">Lothar Roessig</name><affiliation wicri:level="1"><nlm:aff id="A2">Bayer HealthCare, Wuppertal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer HealthCare, Wuppertal</wicri:regionArea><wicri:noRegion>Wuppertal</wicri:noRegion><wicri:noRegion>Wuppertal</wicri:noRegion><wicri:noRegion>Wuppertal</wicri:noRegion></affiliation></author><author><name sortKey="Greenberg, Barry H" sort="Greenberg, Barry H" uniqKey="Greenberg B" first="Barry H." last="Greenberg">Barry H. Greenberg</name><affiliation wicri:level="2"><nlm:aff id="A3">University of California at San Diego, San Diego, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California at San Diego, San Diego, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sato, Naoki" sort="Sato, Naoki" uniqKey="Sato N" first="Naoki" last="Sato">Naoki Sato</name><affiliation wicri:level="1"><nlm:aff id="A4">Nippon Medical School Musashi-Kosugi Hospital, Kawasaki, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nippon Medical School Musashi-Kosugi Hospital, Kawasaki, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Shinagawa, Kaori" sort="Shinagawa, Kaori" uniqKey="Shinagawa K" first="Kaori" last="Shinagawa">Kaori Shinagawa</name><affiliation wicri:level="3"><nlm:aff id="A5">Office of New Drug II, Pharmaceuticals and Medical Devices Agency, Chiyoda-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Office of New Drug II, Pharmaceuticals and Medical Devices Agency, Chiyoda-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name><affiliation wicri:level="1"><nlm:aff id="A6">Gleneagles Hospital, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Gleneagles Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Kwok, Bernard W K" sort="Kwok, Bernard W K" uniqKey="Kwok B" first="Bernard W. K." last="Kwok">Bernard W. K. Kwok</name><affiliation wicri:level="1"><nlm:aff id="A7">Farrer Park Medical Centre, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Farrer Park Medical Centre</wicri:regionArea></affiliation></author><author><name sortKey="Reyes, Eugenio B" sort="Reyes, Eugenio B" uniqKey="Reyes E" first="Eugenio B." last="Reyes">Eugenio B. Reyes</name><affiliation wicri:level="1"><nlm:aff id="A8">Manila Doctors Hospital, Manila, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>Manila Doctors Hospital, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><affiliation wicri:level="3"><nlm:aff id="A9">Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Pieske, Burkert" sort="Pieske, Burkert" uniqKey="Pieske B" first="Burkert" last="Pieske">Burkert Pieske</name><affiliation wicri:level="3"><nlm:aff id="A10">Charité University Medicine, Campus Virchow Klinikum, and German Heart Center Berlin, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité University Medicine, Campus Virchow Klinikum, and German Heart Center Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Greene, Stephen J" sort="Greene, Stephen J" uniqKey="Greene S" first="Stephen J." last="Greene">Stephen J. Greene</name><affiliation wicri:level="2"><nlm:aff id="A1">Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Ambrosy, Andrew P" sort="Ambrosy, Andrew P" uniqKey="Ambrosy A" first="Andrew P." last="Ambrosy">Andrew P. Ambrosy</name><affiliation wicri:level="2"><nlm:aff id="A1">Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Kelly, Jacob P" sort="Kelly, Jacob P" uniqKey="Kelly J" first="Jacob P." last="Kelly">Jacob P. Kelly</name><affiliation wicri:level="2"><nlm:aff id="A1">Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation wicri:level="4"><nlm:aff id="A11">Inserm Centre d’Investigation Clinique CIC 1433, UMR 1116, CHU de Nancy, Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm Centre d’Investigation Clinique CIC 1433, UMR 1116, CHU de Nancy, Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name><affiliation wicri:level="2"><nlm:aff id="A12">University of Michigan School of Medicine, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan School of Medicine, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S. P." last="Lam">Carolyn S. P. Lam</name><affiliation wicri:level="1"><nlm:aff id="A13">National Heart Centre Singapore and Duke-National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>National Heart Centre Singapore and Duke-National University of Singapore</wicri:regionArea></affiliation></author></analytic><series><title level="j">JACC. Heart failure</title><idno type="ISSN">2213-1779</idno><idno type="eISSN">2213-1787</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Heart failure (HF) is a major and increasing global public health problem. In Asia, aging populations and recent increases in cardiovascular risk factors have contributed to a particularly high burden of HF with similarly poor outcomes compared to the rest of the world. Representation of Asians in landmark HF trials has been variable. In addition, HF patients from Asia demonstrate clinical differences from other geographic regions. Thus, the generalizability of some clinical trials results to the Asian population remains uncertain. In this manuscript, we review differences in the HF phenotype, management and outcomes in patients from East and Southeast Asia. We describe lessons learned in Asia from recent HF registries and clinical trial databases and outline strategies to improve the potential for success in future trials. This review is based on discussions between scientists, clinical trialists, industry representatives and regulatory representatives at the CardioVascular Clinical Trialist Asia Forum on July 4, 2014.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Japon</li><li>Philippines</li><li>Singapour</li><li>États-Unis</li></country><region><li>Berlin</li><li>Californie</li><li>Caroline du Nord</li><li>Grand Est</li><li>Lorraine (région)</li><li>Michigan</li><li>Région de Kantō</li><li>Victoria (État)</li></region><settlement><li>Berlin</li><li>Melbourne</li><li>Nancy</li><li>Tokyo</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Mentz, Robert J" sort="Mentz, Robert J" uniqKey="Mentz R" first="Robert J." last="Mentz">Robert J. Mentz</name></region><name sortKey="Ambrosy, Andrew P" sort="Ambrosy, Andrew P" uniqKey="Ambrosy A" first="Andrew P." last="Ambrosy">Andrew P. Ambrosy</name><name sortKey="Greenberg, Barry H" sort="Greenberg, Barry H" uniqKey="Greenberg B" first="Barry H." last="Greenberg">Barry H. Greenberg</name><name sortKey="Greene, Stephen J" sort="Greene, Stephen J" uniqKey="Greene S" first="Stephen J." last="Greene">Stephen J. Greene</name><name sortKey="Kelly, Jacob P" sort="Kelly, Jacob P" uniqKey="Kelly J" first="Jacob P." last="Kelly">Jacob P. Kelly</name><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name></country><country name="Allemagne"><noRegion><name sortKey="Roessig, Lothar" sort="Roessig, Lothar" uniqKey="Roessig L" first="Lothar" last="Roessig">Lothar Roessig</name></noRegion><name sortKey="Pieske, Burkert" sort="Pieske, Burkert" uniqKey="Pieske B" first="Burkert" last="Pieske">Burkert Pieske</name></country><country name="Japon"><noRegion><name sortKey="Sato, Naoki" sort="Sato, Naoki" uniqKey="Sato N" first="Naoki" last="Sato">Naoki Sato</name></noRegion><name sortKey="Shinagawa, Kaori" sort="Shinagawa, Kaori" uniqKey="Shinagawa K" first="Kaori" last="Shinagawa">Kaori Shinagawa</name></country><country name="Singapour"><noRegion><name sortKey="Yeo, Daniel" sort="Yeo, Daniel" uniqKey="Yeo D" first="Daniel" last="Yeo">Daniel Yeo</name></noRegion><name sortKey="Kwok, Bernard W K" sort="Kwok, Bernard W K" uniqKey="Kwok B" first="Bernard W. K." last="Kwok">Bernard W. K. Kwok</name><name sortKey="Lam, Carolyn S P" sort="Lam, Carolyn S P" uniqKey="Lam C" first="Carolyn S. P." last="Lam">Carolyn S. P. Lam</name></country><country name="Philippines"><noRegion><name sortKey="Reyes, Eugenio B" sort="Reyes, Eugenio B" uniqKey="Reyes E" first="Eugenio B." last="Reyes">Eugenio B. Reyes</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name></region></country><country name="France"><region name="Grand Est"><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4893168
|texte= Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27256745" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |